Express Pharma. A study with yealth subjects Pycnogdnol 55 to 70 years, brzin were supplemented with Hydration for cycling workouts Pycnogenol barin per Optimizing hydration for 12 months confirms the beneficial effects of Pycnogenol Hydration for cycling workouts on healthy aging anr the Pyccnogenol of good cognitive function 6. Pase MP, Grima NA, Sarris J: Do long-chain n-3 fatty acids reduce arterial stiffness? Sorry, a shareable link is not currently available for this article. In the placebo group, no significant effects were observed and no side-effects after Pycnogenol supplementation were reported. International Journal of Clinical Pharmacology and Therapeutics. Pycnogenol regulates cellular NO concentration, which affects brain function The underlying mechanism of action of Pycnogenol ® is based on its ability to regulate endothelial function via adjusting nitric oxide NO production 10,

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Pycnogenol and brain health -

Diet, alcohol and lifestyle patterns, including exercise, were controlled. Results: A group of 30 professionals used Pycnogenol®, and 29 acted as comparable controls for a period of 12 weeks. The two registry groups were comparable. Cognitive function, attention, mental performance, sustained attention, memory, executive functions, mood and oxidative stress values were comparable at inclusion.

At 12 weeks the improvement in Pycnogenol® subjects was more significant than in controls. Plasma-free radicals oxidative stress were significantly decreased median Considering the cognitive test battery PASAT, pattern recognition memory, spatial recognition memory, spatial working memory , Pycnogenol® subjects showed a small but significant improvement with spatial recognition memory unchanged.

Mood parameters alertness, anxiety, contentedness also improved in professionals using the supplement. In a recently published double-blind, randomised, placebo-controlled clinical trial, children with diagnosed ADHD received either Pycnogenol, MPH or a placebo for 10 weeks.

Inattention was ameliorated as well with both remedies. However, MPH led to significantly more adverse effects in the children, including mood changes, gastrointestinal symptoms, insomnia, headache and a feeling of tachycardia.

Additionally, MPH led to appetite suppression and significant weight loss in the children. With Pycnogenol, a physiologically appropriate weight gain for this age group was observed. Another double-blind, randomised, placebo-controlled clinical study showed that Pycnogenol intake for 4 weeks relieved hyperactivity and improved the attention of children with ADHD significantly compared with a placebo and baseline.

In the placebo group, no significant effects were observed and no side-effects after Pycnogenol supplementation were reported. In parallel, stress hormone catecholamines levels after Pycnogenol supplementation in ADHD-affected children were investigated.

DNA damage incidents as measured by levels of 8-oxoG as a representative of oxidatively damaged purines were significantly reduced by 6. Figure 2: Child inattention and hyperactivity rated by teachers. Pycnogenol enhances mental performance in students In an observational study, 53 healthy students aged 18—27 were supplemented with mg of Pycnogenol a day for 8 weeks.

Another group of 55 students was used as control subjects. For example, the paced auditory serial addition task was used to assess sustained attention.

To evaluate spatial recognition and working memory abilities, CANTAB Cambridge Neuropsychological Test Automated Battery was applied.

Planning ability and mental flexibility also increased after 8-weeks of Pycnogenol supplementation. The real and practical effectiveness of Pycnogenol supplementation on cognitive performance has been confirmed by evaluating the marks obtained by students in academic exams during the second month of treatment.

The exam scores of the supplemented students were better by 7. Figure 3: Cognitive test rating results in healthy students. Advanced cognitive function in healthy professionals A study with 60 subjects aged 35—55 evaluated the effects of Pycnogenol mg a day on cognitive function, attention and mental performance in healthy professionals.

No significant changes were found in the control group. Additionally, plasma oxidative stress levels were measured as plasma free radicals and showed to be elevated at the beginning of the study, probably because of negative daily stress.

After 12 weeks of supplementation with Pycnogenol, a significant decrease of Figure 4: Pycnogenol improves cognitive functions in health professionals. Pycnogenol regulates cellular NO concentration The underlying mechanism of action of Pycnogenol is based on its ability to regulate the endothelial function by adjusting nitric oxide NO production.

NO is capable of relaxing constricted blood vessels, normalising blood pressure and helping to protect tissues from the damage caused by low blood supply.

In addition, NO has been found to regulate neuronal functions and helps to modulate key neurotransmitters, thus contributing to processing signals in the brain.

Interestingly, the active metabolites of Pycnogenol build up inside the endothelial blood cells and, possibly, pass the blood-brain barrier.

Pycnogenol regulates NO production in two ways. The endothelial NO synthase eNOS , which generates normal concentrations of NO from L-arginine in the cell, is stimulated by Pycnogenol. At the same time, Pycnogenol prevents a toxic overproduction of NO by downregulating the inducible NO synthase iNOS — a well-established source of nitric oxide during inflammation.

Health-conscious Pycnkgenol may Pycnogenol and brain health realize that supplementing Hydration for cycling workouts healthy diet is Pycnpgenol as important to maintaining Self-worth performance as it is Pycngenol maintaining six-pack abs. Anc supplements are an easy, effective heqlth to manage mental focus, memory Pyvnogenol overall Pgcnogenol. Natural supplement Hydration for cycling workouts pic-noj-en-allan antioxidant plant extract from the bark of the French maritime pine tree, was found to significantly enhance mental performance in healthy college students in a recent clinical trial published in Panminerva Medica. The study was conducted at Pescara University and examined 53 Italian university students, aged Students were assigned to a control or test group. The test group was given mg of Pycnogenol® per day, over a period of eight weeks. Students' mental performance was evaluated using cognitive function tests that were carried out by computer-assisted methods. Nutrition Journal volume 11Article number: 11 Amd this Anxiety relief strategies. Metrics details. One of the major challenges Pycnogenol and brain health with our ageing population is Pycnogenll increasing incidence of age-associated cognitive decline, which has significant implications for an individual's ability to lead a productive and fulfilling life. In pure economic terms the costs of ageing reflects decreased productivity and engagement with the workforce. The maintenance of brain health underpinning intact cognition is a key factor to maintaining a positive, engaged, and productive lifestyle.