Bird Herbal medicine remedies, Raederstorff D, Weber P, Steinert Polyphenole. Martino Natural supplements for athletes, dos Santos Dias MM, Noratto Guf, Talcott Natural supplements for athletes, Mertens-Talcott SU. Social activity. Study design: Schematic representation of the study workflow. There were significant associations between lower visceral adipose tissue and specific bacterial genera such as Roseburia. Am J Physiol-Endocrinol Metab. Article CAS PubMed Google Scholar Kiesslich R, Goetz M, Angus EM, Hu Q, Guan Y, Potten C, et al.

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Polyphenols and gut health -

contributed an original research article which reported the protective effects of chlorogenic acid a key coffee polyphenol against indomethacin-induced gastrointestinal inflammation and mucosa damage. Based on cecal microbiota transplantation approaches, they revealed that chlorogenic acid helped maintain intestinal integrity and alleviate inflammatory responses, primarily by inhibiting the growth of Bacteroides and the accumulation of Bacteroides -derived LPS.

Colorectal cancer CRC is one of the most prevalent cancers in the world. In this topic, Ding et al. and Long et al. reviewed the potential of polyphenols to protect against CRC. They provided comprehensive information on understanding the regulatory mechanisms involved, including modulations of the intestinal microbiota, inflammation, as well as cancer cell proliferation and apoptosis-related signaling.

Also, Chen et al. explored the effects of berberine BBR on inhibiting colorectal cancer. These articles are expected to help in the development of future applications of dietary polyphenols in clinical intervention strategies, especially for CRC therapies and prevention. Gut microbiota dysbiosis is closely related to the development of metabolic disease, such as obesity.

Zhao et al. found that monosodium glutamate MSG -induced abdominal obesity, accompanied by gut microbiota dysbiosis, contributes to neuronal damage in the hypothalamus. Dietary quercetin modulated the gut microbiota, alleviated hypothalamic damage and down-regulated liver RetSat expression, thus ameliorating abdominal obesity.

Ding et al. showed that honokiol supplementation improved obesity by regulating the intestinal microbiota and its production of metabolites, and found that sex may be an important factor in determining honokiol activity in obese mice induced by a high-fat diet-induced obese mice.

The gastrointestinal tract is the organ within the body, and its actions play a significant role in shaping the functionality, integrity and composition of the gut microbiota.

In the gastrointestinal tract, dietary polyphenols remain largely unabsorbed and accumulate in the large intestine, where they can undergo metabolism by intestinal microbes. In their article, Ray and Mukherjee describe the fates of dietary polyphenols within the gastrointestinal tract and link this with intestinal microbial ecology, biological activities, and human well-being and disease.

Recent studies suggest that there is a potential link between the development of chronic kidney disease CKD and functional disorders of the gastrointestinal system.

A review presented by Bao et al. showed that polyphenols, such as anthocyanin, catechin, chlorogenic acid, and resveratrol, can regulate the intestinal microbiota. These polyphenols can reduce kidney injury by inhibiting pathogenic bacteria and decreasing host inflammation.

Liver diseases represent a major health burden worldwide. The gut microbiome is often involved in liver diseases and may act via the so-called gut-liver axis. Fu et al. showed that a high-fat diet promotes macrophage-mediated hepatic inflammation and aggravates diethylnitrosamine-induced hepatocarcinogenesis in mice.

A study by He et al. showed Holly Ilex latifolia Thunb. polyphenol extracts could alleviate hepatic damage caused by diquat, a powerful herbicide with strong hepatotoxicity, in challenged piglets. Another study by Luo et al. Farmed animals remain the main human-consumed sources of protein, and their production requires significant antimicrobial use AMU.

Hasted et al. reviewed the immunostimulatory potential of fruits and their extracts in poultry, and showed they had great promise as a replacement for antibiotic applications in poultry production to maintain poultry health and reduce public health risks.

A research article contributed by Cao et al. integrated microbiome and metabolomics approaches to revealed that a polyphenol-rich grape seed extract could be used as an antibiotic substitute in broiler chickens.

Pathogenic microbes, such as Methanobrevibacter , were significantly and negatively correlated with polyphenol intake. A separate study of healthy subjects showed that four weeks of whole grape powder supplementation the equivalent of two servings of grapes significantly increased the alpha diversity of the microbiome while specifically improving levels of Akkermansia muciniphila.

This species is highly beneficial as it stimulates the production of mucin, which serves as a protective layer for the gut lining. In fact, participants in this study experienced a 6.

For this reason, Akkermansia muciniphila has been studied for its modulatory effects on weight , insulin sensitivity , inflammation , and cardiovascular health.

Interestingly, intestinal permeability during exercise may aid in increasing the levels of polyphenols found in systemic circulation. A group of walkers and runners received flavonoid supplementation flavanols, quercetin, and anthocyanins for two weeks prior to exercise.

After exercise, there was an elevation in gut-derived polyphenols. Researchers think this result could have been due to the acute permeability that occurs during intense exercise, and the increase in polyphenols may aid in attenuating inflammation.

Exercise has also been shown to increase microbial diversity , which can impact levels of polyphenol metabolites. Catechins and epicatechins are secondary plant metabolites belonging to the flavanol group of flavonoids.

Green tea is a rich source of catechins, but catechins and epicatechins can also be found in black tea, red wine, cocoa, and fruit such as pomegranates, pears, and cherries. An in vitro study showed that Akkermansia muciniphila can metabolize epigallocatechingallate EGCG in the presence of either mucin or glucose, but not in isolation.

This result not only highlights the importance of maintaining a healthy gastrointestinal mucosal layer, but also of eating polyphenol-rich foods in their whole form. While many studies look at isolated phenolic compounds, consuming whole foods that contain carbohydrates and fiber may be synergistically beneficial for the microbiota.

Genetic expression related to leptin a satiety hormone and the development of fat tissue were also altered. Anthocyanins are known for providing pigments to richly-colored red, blue, and purple fruits and vegetables such as blueberries, strawberries, blackberries, raspberries, apples, and red cabbage.

Researchers in New Zealand sought to further understand the role that anthocyanins play in promoting microbial diversity. They looked at the polyphenolic composition of two different apples with red and white flesh. The white-fleshed apple had higher amounts of catechins and epicatechins, while the red-fleshed apple was rich in quercetins and cyanidins.

The red-fleshed apple increased the abundance of Lactobacillus and Butyricicoccus and decreased Roseburia and Ruminococcus. This is an interesting finding since Roseburia produces butyrate, an important short-chain fatty acid.

The two apples also upregulated the expression of 18 genes, 16 of which were related to immunity. This study serves as a good reminder to include many kinds of foods in the diet since varieties of the same fruit can contain different phytochemicals.

Anthocyanins have been studied for their effects on metabolic health by way of the microbiome. Mice treated with anthocyanins and proanthocyanidins exhibited improved insulin sensitivity.

The mice were fed a high fat, high sucrose HFHS diet, and those that also received proanthocyanidin supplementation experienced less weight gain and adipose tissue accumulation compared to those only on the HFHS diet.

Germ-free mice that received a fecal microbiota transplant from the HFHS mice experienced consistent metabolic changes with the first group, suggesting that the microbiota was responsible for the polyphenolic effects. Dietary analyses of adults in northern Germany demonstrated that higher intakes of anthocyanins were associated with lower levels of visceral adipose tissue , which is the fat that accumulates around organs.

A higher intake of anthocyanins also correlated with greater microbial diversity and abundance. There were significant associations between lower visceral adipose tissue and specific bacterial genera such as Roseburia.

Finally, a small group of overweight and obese adults were given a mixture of inulin, beta-glucan, and anthocyanins the equivalent of two cups of blueberries. After four weeks, participants experienced improved glucose tolerance and satiety. Short-chain fatty acids, which increased in this study, stimulate satiety hormones such as peptide YY.

Resveratrol is a stilbene compound that is found in grapes, wine, peanuts, cocoa, and berries. Some of the health benefits of the Mediterranean diet may be attributed to the resveratrol found in red wine. Trimethylamine N-oxide TMAO is a metabolite produced by gut bacteria that is thought to contribute to cardiovascular disease.

Berry polyphenols metabolism and impact on human gut microbiota and health. Laura Lavefve , a Luke R. This article is part of the themed collection: Berry Health Benefits Symposium.

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Gt here to order Dr. ght dminich Jan 31, Uncategorized 2 comments. The digestive tract is home to the yut microbiomea hfalth complex collection of bacteria and Polyphenols and gut health Polyphnols that Polyhpenols immunity, healthh, metabolism, and more. Strength and conditioning imbalanced Probiotics and brain function, also known as dysbiosis, has been An to a Natural supplements for athletes of conditions such as cardiovascular disease, diabetesobesitydepressionand autoimmunity. As the incidence of these non-communicable diseases continues to increase, it is more important than ever to implement dietary strategies that foster the health and balance of the microbiome. Plenty of research has been conducted on the benefits of using probiotics and prebiotic fibers to positively affect gut ecology, but perhaps more attention should be paid to a remarkable group of compounds known as polyphenols. Dietary polyphenols are a large group of natural plant compounds found in a variety of foods such as fruits, vegetables, tea, coffee, spices, chocolate, and wine.